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How do you feel taking sertraline?

Author

William Rodriguez

Published Jan 06, 2026

Taking sertraline may make you feel sleepy, dizzy and restless, and could affect your eyesight when you start taking it.

How does it feel when sertraline is working?

Sleep, energy, or appetite may show some improvement within the first 1-2 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood and lack of interest in activities may need up to 6-8 weeks to fully improve.

Can you feel sertraline right away?

Will sertraline start working immediately? Unfortunately, sertraline won't make you feel better right away. Sertraline can take several weeks to start working, and it may take up to 12 weeks to be fully effective. If you don't feel a change in your mood right away, it's important to keep taking it.

How does sertraline make you feel at first?

Common side effects during the first week or two of taking Zoloft include nausea, headache, fatigue, and constipation. These side effects should go away once your body gets used to the medication. If you continue to have side effects after a few weeks or experience any serious side effects, call your doctor or 911.

Can sertraline make you feel shaky?

Common side effects may include: indigestion, nausea, diarrhea, loss of appetite; sweating; tremors; or.

32 related questions found

What is the most common side effect of sertraline?

Commonly reported side effects of sertraline include: diarrhea, dizziness, drowsiness, dyspepsia, fatigue, insomnia, loose stools, nausea, tremor, headache, paresthesia, anorexia, decreased libido, delayed ejaculation, diaphoresis, ejaculation failure, and xerostomia.

How do I know if sertraline is working for anxiety?

According to the National Alliance on Mental Illness, some of the earliest signs that Zoloft is working are improvements in sleep, energy, or appetite. These improvements could happen one to two weeks into taking the medication.

Why does sertraline make you feel worse at first?

SSRIs release two chemicals in the brain that kick in at different times, causing a period of negative effects on mental health, the authors report. The first chemical is serotonin, which is released very soon after an SSRI is taken but might not lessen depressive symptoms until after a couple of weeks.

How do I know if antidepressants are working?

How do I know if my antidepressant works? When you start taking an antidepressant, you should begin to function better in your daily life before you start feeling better, says Dr. Michael McGee. In other words, you should begin sleeping better, eating better, and having more energy.

Does sertraline cause weight gain?

Like any medication, antidepressants in the class of selective serotonin reuptake inhibitors (SSRIs) have potential side effects. For some people who take an SSRI such as Prozac (fluoxetine) or Zoloft (sertraline), one of these possible side effects is weight gain.

Can sertraline make you feel sick after 1 tablet?

In fact, nausea is often cited as the number one side effect of selective serotonin reuptake inhibitors (SSRIs) used to treat major depression and anxiety disorders. 1 In some cases, nausea and vomiting can become so severe or persistent that a person has no other option but to stop treatment.

Does your brain go back to normal after antidepressants?

"The fact that antidepressant withdrawal can be so prolonged suggests that the drug has changed the brain and that those changes are taking a very long time to return to normal and it may be the case that sometimes they don't go back to normal."

Can sertraline worsen anxiety?

Jitteriness/anxiety syndrome occurs with antidepressants in general [3], and there have also been reports of sertraline causing jitteriness/anxiety syndrome [4], though this is generally considered very rare [2].

Is 25mg of sertraline enough for anxiety?

What's a Normal Sertraline Dosage for Anxiety? Sertraline is typically prescribed at a dosage of 25mg per day as a treatment for panic disorder, social anxiety disorder and post-traumatic stress disorder. For obsessive-compulsive disorder, it may be prescribed at a slightly higher starting dosage of 50mg per day.

What should you avoid when taking sertraline?

Generally, individuals taking sertraline will need to avoid nonsteroidal anti-inflammatory drugs (NSAIDs) like naproxen, aspirin, ibuprofen; blood thinners; and other medications that increase serotonin levels. Too much serotonin can cause serotonin syndrome.

How quickly does sertraline work?

Official Answer. Zoloft (sertraline), a common selective serotonin reuptake inhibitor (SSRI) antidepressant, can take about 4 to 6 weeks of regular dosing to reach its full therapeutic effect for depression. The initial effects may begin within the first 1 to 2 weeks of treatment.

Can sertraline cause a racing heart?

Zoloft (sertraline) can affect the natural rhythm of your heart and cause it to beat abnormally. If you experience symptoms such as fast heart rate, dizziness, difficulty breathing or chest pain, go to the emergency room right away.

How can I calm my anxiety?

12 Ways to Calm Your Anxiety

  1. Avoid caffeine. Caffeine is well-known as an anxiety inducer . ...
  2. Avoid alcohol. Feelings of anxiety can be so overwhelming that you might feel the urge to have a cocktail to help you relax. ...
  3. Write it out. ...
  4. Use fragrance. ...
  5. Talk to someone who gets it. ...
  6. Find a mantra. ...
  7. Walk it off. ...
  8. Drink water.

Does sertraline help with stress?

Social Anxiety Disorder (SAD). Studies show that sertraline is an effective treatment for social anxiety disorder. In a 2006 study, researchers found that sertraline performed significantly better than a non-therapeutic placebo in reducing social anxiety symptoms.

What do panic attacks feel like?

A panic attack is an intense wave of fear characterized by its unexpectedness and debilitating, immobilizing intensity. Your heart pounds, you can't breathe, and you may feel like you're dying or going crazy. Panic attacks often strike out of the blue, without any warning, and sometimes with no clear trigger.

Do antidepressants shorten your life?

The analysis found that in the general population, those taking antidepressants had a 33 percent higher risk of dying prematurely than people who were not taking the drugs. Additionally, antidepressant users were 14 percent more likely to have an adverse cardiovascular event, such as a stroke or a heart attack.

Can sertraline damage your brain?

The study -- conducted in nonhuman primates with brain structures and functions similar to those of humans -- found that the antidepressant sertraline, a selective serotonin reuptake inhibitor (SSRI) marketed as Zoloft, significantly increased the volume of one brain region in depressed subjects but decreased the ...

What does sertraline do to the brain?

2 SSRIs work by blocking the reabsorption of serotonin into neurons in the brain. Serotonin is a chemical neurotransmitter, which transmits electrical impulses from one neuron to the next.

Why is my sertraline making me feel weird?

It's not uncommon to feel dizzy during the first few weeks of using sertraline. Like other common side effects, this is thought to be a result of your body adjusting to the medication. Dizziness is a short-term side effect of sertraline that usually doesn't persist for longer than two to four weeks.

Why do I feel so ill on sertraline?

When you take an SSRI like Zoloft, your serotonin levels increase. This stimulates serotonin receptors in the brain and gastrointestinal (GI) tract. This stimulation can cause GI-related symptoms like: Nausea.