How do you stop withdrawal symptoms from antidepressants?
Emily Ross
Published Jan 16, 2026
Never stop "cold turkey." In many cases, the best way to stop taking most antidepressants is to slowly cut back your dose under the guidance of your doctor. This is called tapering. Tapering helps your brain adjust to the chemical changes and can help prevent discontinuation symptoms.
What helps with withdrawal symptoms from antidepressants?
When experiencing withdrawal symptoms or antidepressant discontinuation syndrome, increasing physical exercise or changing the diet to include more fresh food may help ease symptoms by making a person feel reinvigorated and less lethargic.
How long do antidepressant withdrawal symptoms last?
Withdrawal symptoms usually come on within 5 days of stopping the medicine and generally last 1 to 2 weeks. Some people have severe withdrawal symptoms that last for several months or more. See your doctor if you get severe withdrawal symptoms after you stop taking antidepressants.
How long does it take to normalize after stopping antidepressants?
Timeline of discontinuation symptoms
In a 2019 review of existing research, the authors noted that it is not uncommon for people to have antidepressant withdrawal symptoms for many weeks or even months. Some studies found that 40% of people had symptoms for 6 weeks, while 25% experienced symptoms for 12 weeks or more.
Does your brain go back to normal after antidepressants?
"The fact that antidepressant withdrawal can be so prolonged suggests that the drug has changed the brain and that those changes are taking a very long time to return to normal and it may be the case that sometimes they don't go back to normal."
15 related questions foundDo antidepressants shorten your lifespan?
The analysis found that in the general population, those taking antidepressants had a 33 percent higher risk of dying prematurely than people who were not taking the drugs. Additionally, antidepressant users were 14 percent more likely to have an adverse cardiovascular event, such as a stroke or a heart attack.
What happens to your brain when you stop taking antidepressants?
Quitting an antidepressant suddenly may cause symptoms within a day or two, such as: Anxiety. Insomnia or vivid dreams. Headaches.
What helps Lexapro withdrawal?
Some general tips for coping with Lexapro withdrawal symptoms include:
- eating a healthful and nutritious diet.
- exercising regularly.
- taking all other medications according to the prescription.
- completing the tapering process.
- tracking changes in mood on a calendar or in a notebook.
Does Benadryl help antidepressant withdrawal?
If you were on a very high dose of Paxil (paroxetine) or Effexor (venlafaxine), you may need to take repeated doses of Prozac. Benadryl (diphenhydramine) is an over-the-counter allergy medication that has been reported to help with discontinuation symptoms too, though it has a sedating effect.
What happens when you stop SSRI abruptly?
Quitting without consulting a doctor can be dangerous to your physical and mental health; suicide is often a major concern when SSRIs and similar medications are stopped suddenly. It can also trigger worse symptoms and a relapse of depression or anxiety.
How do I detox my brain from antidepressants?
Antidepressant detox involves gradually stepping down doses until the user can safely stop taking them. “To be able to taper off an antidepressant medication successfully, we want to do it slowly. So, it can take a month or six weeks or two months. But we just simply step the dose down slowly over time.”
What helps with withdrawal symptoms from citalopram?
Restarting Celexa may relieve withdrawal symptoms, but this might not be a desirable solution for many people. Other methods to prevent and treat Celexa withdrawal symptoms include drug tapering, which refers to gradually reducing the dosage over a fixed period, and cognitive behavioral therapy (CBT).
How can I get off antidepressants naturally?
Never stop "cold turkey." In many cases, the best way to stop taking most antidepressants is to slowly cut back your dose under the guidance of your doctor. This is called tapering. Tapering helps your brain adjust to the chemical changes and can help prevent discontinuation symptoms.
How long does it take for serotonin levels to return to normal after SSRI?
In cases where serotonin syndrome is only present in a mild form, symptoms may be alleviated within 24 hours of discontinuing the medication causing the uptake in serotonin. However, some antidepressants can cause symptoms to last longer as serotonin levels may take weeks to return to normal.
How long does desvenlafaxine withdrawal last?
Generally, Pristiq withdrawal symptoms begin to appear between two and four days after the last dose. They may last anywhere from four to six weeks (or longer) depending on your dosage and how long you've been taking Pristiq.
How long does citalopram withdrawal last?
For most people, Celexa withdrawal begins within three to six days of your last dose. Symptoms may continue for anywhere from five days to and in some cases over one month.
When do antidepressant withdrawals peak?
The symptoms typically last 1-3 weeks and will typically peak within the first week. Symptoms can be relieved within 24 hours by restarting the antidepressant medication.
How do I wean off Lexapro 10mg?
Taper Off Medication Slowly
The most effective way to minimize symptoms of withdrawal is to slowly taper off your medication. Tapering involves adjusting your dose by a small amount, gradually decreasing until your body gets used to lower levels of the medication.
Is Lexapro easy to come off?
Lexapro withdrawal symptoms can be severe, particularly if you attempt to stop abruptly. Instead, the dosage should be slowly tapered down over a period of time and under the guidance of medical professionals who can help prevent or mitigate any withdrawal symptoms.
How long until Lexapro is out of your system?
How Long Does Lexapro Stay In Your Urine And Blood? Because it takes around five half-lives for a drug to be cleared from your system, and because the half-life of Lexapro is up to 32 hours, it can take up to 160 hours, or roughly six days, to clear Lexapro from your bloodstream.
What does antidepressant withdrawal feel like?
Overview. Antidepressant withdrawal can make you feel edgy and out of sorts. You may feel like you have the flu (sluggish with a headache and nausea), have trouble sleeping and concentrating, and experience anxiety and even thoughts of suicide.
How long does discontinuation syndrome last?
Discontinuation symptoms may occur in either case, especially if a drug is stopped abruptly. Symptoms usually start two to four days after stopping the medicine. They usually go away after four to six weeks. In rare cases, they may last as long as a year.
Do brain zaps go away?
Many antidepressants retain serotonin in the brain for longer periods of time than natural, and when the serotonin levels are suddenly decreased, it causes some instability in the brain,causing it to misfire or “zap.” Many wonder “how long do brain zaps last?” Theanswer to that question depends on the medication in ...
What is the strongest antidepressant?
The most effective antidepressant compared to placebo was the tricyclic antidepressant amitriptyline, which increased the chances of treatment response more than two-fold (odds ratio [OR] 2.13, 95% credible interval [CrI] 1.89 to 2.41).
Do antidepressants cause dementia?
Certain antidepressants and bladder medications are linked to increased risk of dementia, according to new University of East Anglia research funded by Alzheimer's Society and published today in the British Medical Journal.