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Is it normal to feel worse after starting Lexapro?

Author

Rachel Ellis

Published Jan 21, 2026

During the first few weeks' people commonly experience some side effects or feel worse before they begin to feel better. Although the newer Selective serotonin reuptake inhibitors (SSRIs) usually have fewer or less severe side effects than tricyclic antidepressants, various side effects can occur with them all.

Does Lexapro make you feel worse in the beginning?

There's a paradoxical period when a person first starts an antidepressant: they may actually begin to feel worse before feeling better. The underlying cause of this phenomenon is a bit of a mystery, but a new study from researchers at Otto-von-Guericke University in Germany explains why this might occur.

Can Lexapro make you feel worse before better?

When you start an antidepressant medicine, you may feel worse before you feel better. This is because the side effects often happen before your symptoms improve. Remember: Over time, many of the side effects of the medicine go down and the benefits increase.

How long will I feel worse on Lexapro?

Like most drugs, there are many short and long-term effects associated with Lexapro. The side effects of Lexapro may be different in adults and children and may vary from person to person. The most common side effects occur within the first and second weeks and may improve as you continue to take the drug.

Can Lexapro make you more anxious at first?

Can Lexapro cause anxiety? Some patients experience new or worsened anxiety when taking Lexapro. 13 If you are taking Lexapro or escitalopram and feel like your anxiety is increasing, contact your doctor to discuss whether this is the right medication for you or if the dosage should be adjusted based on these effects.

36 related questions found

How does Lexapro make you feel the first week?

Headache, nausea, diarrhea, dry mouth, increased sweating, feeling nervous, restless, fatigue, or having trouble sleeping (insomnia). These will often improve over the first week or two as you continue to take the medication.

Can Lexapro work the first day?

It's important to recognize that you will not experience immediate relief from taking Lexapro. It can take anywhere from one to four weeks to feel better once you start taking this drug. You might notice improvements in your sleep, energy levels, and appetite within the first week or two.

Does Lexapro make your anxiety worse?

new or worse anxiety or panic attacks. feeling restless, angry, or irritable. trouble sleeping. increased activity (doing more than what is normal for you)

Is it possible for Lexapro to make anxiety worse?

SSRIs are thought to improve mood by boosting serotonin activity in the brain. But serotonin is not always a bed of roses. In the early days of treatment, it can increase levels of fear and anxiety and even suicidal thinking in some younger people. As a result, patients may stop using the treatment after a few weeks.

What is the success rate of Lexapro?

The overall response and remission rates after escitalopram monotherapy were 68.4% and 46.4%, respectively. The response rate was 76.9%, 63.7%, and 63.0%, in mild, moderate, and moderate–severe subgroups, respectively, showing significant difference among them (P < .

Is 10 mg of Lexapro enough?

The recommended dose of Lexapro is 10 mg once daily. A flexible-dose trial of Lexapro (10 to 20 mg/day) demonstrated the effectiveness of Lexapro [see Clinical Studies]. If the dose is increased to 20 mg, this should occur after a minimum of three weeks. The recommended dose of Lexapro is 10 mg once daily.

Why do antidepressants make anxiety worse at first?

Artificially increasing the activity of the DRN-to-BNST neurons enhanced anxiety-like behaviors in the mice. UNC scientists found that the serotonin output from the DRN neurons activates their target neurons in the BNST through a specific subset of serotonin receptors, known as 2C receptors.

Is 5mg Lexapro enough for anxiety?

Social anxiety disorder: Usual dosage is 10 mg once daily. Usually 2-4 weeks are necessary to obtain symptom relief. The dose may subsequently, depending on individual patient response, be decreased to 5 mg or increased to a maximum of 20 mg daily.

How long does it take for Lexapro to work for anxiety?

Most people report feeling the effects of their Lexapro within 4 weeks. It can take some people as little as a day or as long as 6 weeks to feel the effects of their treatment.

Is it better to take Lexapro in the morning or at night?

What is the best time of day to take Lexapro for anxiety? While Lexapro can be taken in the morning or the evening, because it may cause trouble sleeping, some people find it better to take it in the morning.

Is Lexapro good for panic attacks?

Now established to be effective in treating panic disorder, SSRIs include medications such as Prozac (Fluoxetine), Paxil (Paroxetine), Celexa (Citalopram), Lexapro (Escitalopram), Luvox (Fluvoxamine), and Zoloft (Sertraline).

Do Lexapro side effects go away?

Lexapro side effects are usually temporary. Many, such as dry mouth, headache, and nausea, go away within a couple weeks as the body adjusts to Lexapro. Unfortunately, severe side effects may persist longer.

How long do the side effects of Lexapro last?

Generally, side effects from Lexapro should clear up within 2 weeks of taking the drug. Although some side effects can be serious, these reactions are rare. If a person has concerns about Lexapro, they should speak to their doctor.

Can too much serotonin cause anxiety?

It has long been suggested that over-activity of the serotonin system may relate to mood disorders such as depression and anxiety, as these seem characterized by too much withdrawal and avoidance.

Is 20mg of Lexapro better than 10mg?

Conclusion: Escitalopram 10 mg/d was the optimal dose for the treatment of moderate DSM-IV MDD, while escitalopram 20 mg/d was an effective dose in patients with moderate to severe depression.

Is 10mg of Lexapro more effective than 20mg?

A daily dose of 20 mg may not be more effective than 10 mg daily for treatment of depression. The dose for treating generalized anxiety disorder is 10 mg once daily. Lexapro can be taken with or without food.

Does Lexapro give you energy or make you tired?

Serotonin reuptake inhibitors (SSRIs) like escitalopram (Lexapro), citalopram (Celexa), paroxetine (Paxil), and fluoxetine (Prozac), taken for depression or anxiety, can make you feel sleepy.

Is 5 mg of Lexapro enough?

It is concluded that doses of 5-20 mg escitalopram are effective and well tolerated in the short- and long-term treatment of generalised SAD.

Is Lexapro worth taking for anxiety?

Lexapro (escitalopram) is good for treating depression and anxiety. It's generally well-tolerated and has fewer drug interactions than other antidepressants.

What are the cons of Lexapro?

Downsides

Insomnia or drowsiness, sexual dysfunction, nausea, dry mouth, and increased sweating. As with other antidepressants, Lexapro may increase the risk of suicidal thoughts or behavior; the risk is higher in children and young adults aged less than 24.