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What are the serious side effects of azithromycin?

Author

Rachel Ellis

Published Jan 16, 2026

The drug's active ingredient, azithromycin, can cause rare but serious side effects such as severe or life-threatening allergic reactions, irregular heartbeats, Clostridium difficile-associated diarrhea and liver damage. More common side effects include nausea or vomiting, diarrhea and abdominal pain.

What is the most significant adverse effect of azithromycin?

This medicine may increase the risk of serious heart or blood vessel problems. Call your doctor right away if you have blurred vision, chest pain, confusion, lightheadedness, dizziness, fainting, fast or irregular heartbeat, trouble breathing, or unusual tiredness or weakness.

Should I be worried about azithromycin?

[3-12-2013] The U.S. Food and Drug Administration (FDA) is warning the public that azithromycin (Zithromax or Zmax) can cause abnormal changes in the electrical activity of the heart that may lead to a potentially fatal irregular heart rhythm.

What are 3 adverse reactions to azithromycin?

SIDE EFFECTS: Stomach upset, diarrhea/loose stools, nausea, vomiting, or abdominal pain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Can azithromycin be fatal?

The Food and Drug Administration announced in 2013 that azithromycin can cause a potentially fatal disturbance in a person's heart rhythm.

36 related questions found

Does azithromycin cause heart attacks?

Azithromycin was associated with a significantly increased hazard of cardiovascular death (hazard ratio [HR], 1.82; 95% CI, 1.23-2.67) but not sudden cardiac death (HR, 1.59; 95% CI, 0.90-2.81) within 5 days of exposure. No increases in risk were found 6 to 10 days after exposure.

Which antibiotics cause sudden death?

Within 5 days of taking azithromycin, patients are more than twice as likely to die from all causes as people who take another commonly prescribed antibiotic, amoxicillin, a U.S. study suggests.

How can I reduce the side effects of azithromycin?

If you have diarrhea after taking azithromycin (Zithromax), try taking probiotic supplements to help lessen this side effect. Separate the probiotic from azithromycin (Zithromax) by at least 1 hour to prevent azithromycin (Zithromax) from killing the "good" bacteria from the probiotic.

Can azithromycin raise blood pressure?

Treatment with erythromycin was found to increase the risk of low blood pressure almost 6-fold, while clarithromycin increased the risk almost 4-fold. In contrast, azithromycin did not increase the risk of hypotension.

Can azithromycin cause breathlessness?

Call your doctor at once if you have: severe stomach pain, diarrhea that is watery or bloody; fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out); or.

Who should not take azithromycin?

Who should not take AZITHROMYCIN?

  • diarrhea from an infection with Clostridium difficile bacteria.
  • low amount of magnesium in the blood.
  • low amount of potassium in the blood.
  • myasthenia gravis, a skeletal muscle disorder.
  • hearing loss.
  • torsades de pointes, a type of abnormal heart rhythm.
  • slow heartbeat.

Does Zpack make your heart race?

Also sold under the names Zithromax and Zmax, and often called a Z-pack, the antibiotic can cause changes in the electrical system of the heart, leading to arrhythmia. The medication can also trigger a form of rapid heartbeat called torsades de pointes.

Is Zpack safe?

Z-paks have been around long enough that the drug is known to be well tolerated by most patients, however, it does carry some risks. According to the U.S. Food and Drug Administration, the pills can cause abnormal changes in the heart's electrical activity that may lead to a fatal heart rhythm.

What does azithromycin do in the body?

Azithromycin is in a class of medications called macrolide antibiotics. It works by stopping the growth of bacteria. Antibiotics such as azithromycin will not work for colds, flu, or other viral infections.

How long does azithromycin stay in your system?

Official Answer. Azithromycin will be in your system for around 15.5 days, after the last dose. Azithromycin has an elimination half-life of 68 hours. The prolonged terminal half-life is thought to be due to extensive uptake and subsequent release of drug from tissues.

Why is azithromycin given in Covid?

Azithromycin use was associated with a reduction in mortality and ventilation days in other viral infections. These properties could be beneficial throughout the COVID-19. However, the evidence of its use is scarce and of low quality.

Can azithromycin cause low heart rate?

Conclusions: Recommended azithromycin doses can cause at least moderate bradycardia and hypothermia in vulnerable pediatric patients, adverse effects that should prompt appropriate monitoring and which may take many days to resolve.

What medications should not be taken with antibiotics?

So, it's a good idea to review the potential for interactions with commonly prescribed drugs, such as antibiotics. Here are six classes of antibiotic drugs that can interact dangerously with other drugs.
...
Fluoroquinolones

  • Theophylline.
  • Ropinirole.
  • Probenecid.
  • Tizanidine.
  • Glibenclamide.
  • NSAIDs.
  • Cyclosporine.
  • Cisapride.

Can azithromycin cause atrial fibrillation?

However, some antibiotics have worse gastric tolerance effects like Azithromycin and Erythromycin which can become a trigger for A-Fib by GI stimulation such as nausea or reflux. Medication to counter that side effect can be used, such as acid reducers.”

Can azithromycin make you feel sick?

The drug's active ingredient, azithromycin, can cause rare but serious side effects such as severe or life-threatening allergic reactions, irregular heartbeats, Clostridium difficile-associated diarrhea and liver damage. More common side effects include nausea or vomiting, diarrhea and abdominal pain.

How do you recover from side effects of antibiotics?

It is vital to restore a healthful balance in the gut microbiome after taking a course of antibiotics. People can do this by eating probiotics, prebiotics, fermented foods, and fiber. Probiotics and prebiotics can also help to reduce the side effects of antibiotics.

Can I stop antibiotics if they are making me sick?

Stopping antibiotics when symptoms have substantially resolved appears to be effective and safe for many patients, especially those who are unlikely to have a bacterial infection or who have a self-limiting bacterial infection.

Is Zpack a strong antibiotic?

So, what is a Z-pack actually? Unfortunately, many patients don't know or aren't told that the “Z” in Z-pak stands for azithromycin, which is a powerful macrolide antibiotic. All medicines in this class work by stopping bacteria reproduction, eventually killing the population, and curing the infection.

What is the safest antibiotic?

Penicillins are the oldest of the antibiotics and are generally safe (but they can cause side effects such as diarrhea, skin rash, fever and more). FQs are the newest group of antibiotics.

Is Z pack a steroid?

Is azithromycin a steroid? No. Azithromycin is a macrolide antibiotic that works by inhibiting the growth of bacteria.