What are the side effects of indomethacin 25 mg?
Noah Mitchell
Published Jan 18, 2026
The most common side effects that occur with indomethacin include:
- nausea.
- vomiting.
- heartburn.
- diarrhea.
- stomach pain.
- constipation.
- headache.
- dizziness.
How long is it safe to take indomethacin?
Adults—75 to 150 milligrams (mg) per day, divided into three or four equal doses, and taken for 1 to 2 weeks as determined by your doctor.
How does indomethacin make you feel?
Upset stomach, heartburn, headache, drowsiness, or dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
What can you not take with indomethacin?
Don't take indomethacin with the following NSAIDs unless expressly directed to by your healthcare provider:
- Advil, Motrin (ibuprofen)
- Aleve (naproxen)
- Aspirin.
- Celebrex (celecoxib)
- Mobic (meloxicam)
- Voltaren, Zorvolex, Zipsor (diclofenac)
- Ketorolac2.
What does indomethacin do to your body?
This medication is known as a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation. This effect helps to decrease swelling and pain.
42 related questions foundCan I just stop taking indomethacin?
If you stop taking it: If you don't take your medication, your pain and swelling may get worse. If you take too much: If you take too much indomethacin, you may experience side effects like nausea, vomiting, very bad headaches, confusion, and convulsions.
Does indomethacin affect the kidneys?
Any medication may have some drug interaction that affect the kidneys. Of the medication that you take, Indomethacin can cause kidney function to decline.
Does indomethacin raise blood pressure?
The most widely studied of the NSAID medications is indomethacin, which has been shown to increase mean blood pressure by as much as 5 mm Hg in treated hypertensive patients.
Does indomethacin make you gain weight?
Possible warning signs of some serious side effects that can occur during treatment with this medicine may include black, tarry stools, decreased urination, severe stomach pain, skin rash, swelling of the face, fingers, feet, or lower legs, unusual bleeding or bruising, unusual weight gain, vomiting of blood or ...
Can you take painkillers with indomethacin?
It's important that you never take Indocin and ibuprofen together, unless you have specifically been told to do so by a medical professional. Taking more than on NSAID medication at a time can increase your risk of complications from NSAIDS.
Does indomethacin affect sleep?
Previous studies have demonstrated that some nonsteroidal anti-inflammatory drugs (NSAIDs), specifically aspirin and indomethacin, have acute negative effects on sleep in humans and animals.
What drugs interact with indomethacin?
Some products that may interact with this drug include: aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as valsartan, losartan), cidofovir, corticosteroids (such as prednisone), lithium, methotrexate, "water pills" (diuretics such as furosemide).
Does indomethacin lower uric acid?
Prescription Medicines
Febuxostat(Uloric) reduces uric acid production. Indomethacin(Indocin, Tivorbex) is a stronger NSAID pain reliever. Lesinurad (Zurampic) helps your body get rid of uric acid when you pee. Pegloticase (Krystexxa) breaks down uric acid.
Can indomethacin cause hair loss?
Prescription NSAIDs that may also cause hair loss include: celecoxib (Celebrex), diclofenac (Voltaren), etodolac (Lodine), fenoprofen (Nalfon), indomethacin (Indocin), ketoprofen (Orudis, Oruvail), oxaprozin (Daypro), nabumetone (Relafen), and sulindac (Clinoril).
Is indomethacin good for arthritis?
Descriptions. Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate acute pain and relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis) or gout, such as inflammation, swelling, stiffness, and joint pain.
Does indomethacin affect the heart?
This medicine may raise your risk of having a heart attack or stroke. This is more likely in people who already have heart disease. People who use this medicine for a long time might also have a higher risk.
Does indomethacin increase heart rate?
Indomethacin raised BP and lowered pulse rates in patients taking enalapril but had little effect in patients receiving amlodipine.
Can indomethacin cause liver damage?
Drug induced liver injury from indomethacin is usually mild-to-moderate in severity and transient, but can progress to acute liver failure and death. In large case series, indomethacin is rarely mentioned as a cause of acute liver failure. Rechallenge may lead to recurrence and should be avoided.
How does indomethacin cause renal failure?
Renal impairment occurs in neonates receiving indomethacin for treatment of patent ductus arteriosus. Inhibition of cyclooxygenase within the neonatal kidney results in decreased prostaglandin synthesis and consequent reduction in renal perfusion.
What is arthrex tablets used for?
ARTHREXIN is used to relieve pain and reduce inflammation (swelling, redness and soreness) that may occur in the following conditions: different types of arthritis including rheumatoid arthritis, osteoarthritis, gouty arthritis, ankylosing spondylitis and degenerative joint disease of the hip. gout.
Can I take indomethacin with Tylenol?
by Drugs.com
Yes, you can take Tylenol while taking indomethacin. As long as you do not exceed the recommended daily doses you can safely alternate the medicines, or take together for added pain relief. The usual dose of indomethacin for pain in adults is 20mg 3 times a day or 40mg 2 to three times a day.
What is the best thing to drink if you have gout?
Hence, people with gout should drink coffee with low-fat or skimmed milk and without sugar to prevent attacks. Drinking one to two cups of coffee should do the trick. Lemon water: A study has reported that lemon water or drinks high in vitamin C helps neutralize uric acid in the body.
What is the fastest way to get rid of gout?
How to Get Fast Relief From Gout Attacks
- Over-the-counter pain relievers. ...
- Apply ice to the affected joints. ...
- Drink plenty of water. ...
- Prescription Treatments. ...
- Medications for gout. ...
- Diet changes. ...
- Lifestyle changes.
Which is better for gout ibuprofen or indomethacin?
Consider nonsteroidal anti-inflammatory drugs (NSAIDs) other than indomethacin. Traditionally, indomethacin has been the NSAID of choice for acute attacks of gout; however, other NSAIDs have been shown to be effective in gout,1–8 and indomethacin has never been proven to be any more efficacious.
Can I take ibuprofen and indomethacin at the same time?
ibuprofen indomethacin
Using ibuprofen together with indomethacin is generally not recommended. Combining these medications may increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.