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What can you not mix with Lexapro?

Author

Sarah Smith

Published Jan 18, 2026

Do not use escitalopram with buspirone (Buspar®), fentanyl (Abstral®, Duragesic®), lithium (Eskalith®, Lithobid®), tryptophan, St. John's wort, amphetamines, or some pain or migraine medicines (eg, rizatriptan, sumatriptan, tramadol, Frova®, Imitrex®, Maxalt®, Relpax®, Ultram®, Zomig®).

What interferes with Lexapro?

Drug interactions of Lexapro include monoamine oxidase inhibitors (MAOIs), tryptophan, St. John's wort, meperidine, lithium, triptans, tramadol, warfarin, aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), and other drugs that cause bleeding.

Can you take Lexapro and drink caffeine?

No interactions were found between caffeine and Lexapro.

What to avoid while on antidepressants?

Avoid driving or operating machinery. Avoid caffeine, tobacco and alcohol. Drink plenty of fluids. Take your antidepressant at bedtime if your doctor approves.

Can I take Lexapro with Tylenol?

Interactions between your drugs

No interactions were found between escitalopram and Tylenol.

32 related questions found

Can I take a sleep aid with Lexapro?

Using doxylamine together with escitalopram may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination.

Can I drink on Lexapro?

The combination of Lexapro and alcohol should be avoided due to potentially dangerous side effects. Even a small amount of alcohol can lead to a large amount of unpleasant effects. Mixing these two substances may actually lead to heightened symptoms of depression and anxiety.

Can I take vitamin D with Lexapro?

Interactions between your drugs

No interactions were found between Lexapro and Vitamin D3. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Can you take ibuprofen and Lexapro?

Thank you Answer There is a moderate interaction between ibuprofen and Lexapro escitalopram. The use of NSAIDs non-steroidal anti-inflammatory drugs , like ibuprofen, and SSRI selective serotonin re-uptake inhibitor medications, like Lexapro, increases the risk of gastrointestinal bleeding.

Is it better to take Lexapro in the morning or at night?

What is the best time of day to take Lexapro for anxiety? While Lexapro can be taken in the morning or the evening, because it may cause trouble sleeping, some people find it better to take it in the morning.

Can Lexapro cause weight loss?

Escitalopram may cause weight loss or a decrease in appetite. Teenagers who will be taking it for a long time should have their weight and growth measured on a regular basis.

Can I take Tums with Lexapro?

Interactions between your drugs

No interactions were found between Lexapro and Tums Plus. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Can I take Benadryl with Lexapro?

Using diphenhydrAMINE together with escitalopram may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination.

Does CBD interact with Lexapro?

cannabis (Schedule I substance) escitalopram

Using cannabis (Schedule I substance) together with escitalopram may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating.

Can Lexapro cause dementia?

Antidepressant alternatives that don't increase dementia risk include SSRI antidepressants like escitalopram and sertraline, that don't have strong anticholinergic properties. Amitriptyline is also prescribed off-label for some chronic pain symptoms like neuropathy, fibromyalgia, and chronic tension headaches.

Can I take B12 with Lexapro?

No interactions were found between Lexapro and Vitamin B12.

Can I take multivitamins with Lexapro?

No interactions were found between Lexapro and Vitamins.

Can I take Vitamin C with Lexapro?

Interactions between your drugs

No interactions were found between escitalopram and Vitamin C. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Can I skip a day of Lexapro to drink alcohol?

You may not want to skip having a drink just because you take an antidepressant. But if you want to raise a glass once in a while, you need to do it safely. And don't stop taking your medication just so you can drink. Some doctors think it's OK to drink moderately if you take an SSRI like Lexapro.

Can I have a glass of wine on Lexapro?

To avoid dangerous side effects such as drowsiness and liver problems, it's best not to use alcohol while you take Lexapro. Alcohol may also keep Lexapro from working as well as it should. With or without a drug, alcohol may aggravate your symptoms of anxiety and depression.

Is 10 mg of Lexapro enough?

The recommended dose of Lexapro is 10 mg once daily. A flexible-dose trial of Lexapro (10 to 20 mg/day) demonstrated the effectiveness of Lexapro [see Clinical Studies]. If the dose is increased to 20 mg, this should occur after a minimum of three weeks. The recommended dose of Lexapro is 10 mg once daily.

Can I take melatonin and Lexapro?

Using melatonin together with escitalopram may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination.

Does Lexapro affect memory?

Results: Escitalopram had no significant effect on WM accuracy or reaction time. Preliminary analysis of the imaging data revealed no significant (p(corrected)<0.05) differences in memory-load-dependent activation between conditions.

Does Lexapro insomnia go away?

When Will Lexapro Insomnia Go Away? Some anxious or depressed insomniacs reported an improvement in sleep quality within a month of starting Lexapro – regardless of if the insomnia was caused by the medication or the condition.

Can you mix Adderall with Lexapro?

Combining these medications can also increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle ...