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What else could fibromyalgia be?

Author

Rachel Ellis

Published Jan 06, 2026

Several rheumatic diseases can mimic fibromyalgia. These include sero-negative rheumatoid arthritis, ankylosing spondylitis, Lyme disease, polymyalgia rheumatica and lupus. They have symptoms of widespread pain along with joint involvement. Most rheumatic diseases are treated with medication and physical therapy.

What can be mistaken for fibromyalgia?

Fibromyalgia may be mistaken for one of the following six conditions, among others:

  • Celiac disease or a gluten sensitivity.
  • Hypothyroidism/Hashimoto's disease.
  • Lyme disease and other tick-borne diseases.
  • Rheumatoid arthritis.
  • Chronic fatigue syndrome (myalgic encephalomyelitis)
  • Myofacial pain.

What diseases are linked to fibromyalgia?

Fibromyalgia often co-exists with other conditions, such as:

  • Irritable bowel syndrome.
  • Chronic fatigue syndrome.
  • Migraine and other types of headaches.
  • Interstitial cystitis or painful bladder syndrome.
  • Temporomandibular joint disorders.
  • Anxiety.
  • Depression.
  • Postural tachycardia syndrome.

What conditions can fibromyalgia be mistaken for due to fatigue?

10 Conditions Often Mistaken for Fibromyalgia

  • Chronic fatigue syndrome. Chronic fatigue syndrome (also called ME/CFS) is the condition that is probably most often confused with fibromyalgia. ...
  • Hypothyroidism. ...
  • Lupus. ...
  • Osteoarthritis. ...
  • Rheumatoid arthritis. ...
  • Multiple sclerosis. ...
  • Depression. ...
  • Lyme disease.

How can you tell the difference between fibromyalgia and polymyalgia rheumatica?

Both fibromyalgia and polymyalgia are more common in women than men. Fibromyalgia can occur at any age, but polymyalgia rarely occurs before age 50. The average age of onset is 70. And whereas fibromyalgia is chronic, often lasting a lifetime, polymyalgia usually resolves itself within two years.

39 related questions found

Does fibromyalgia show up in blood work?

Scientists have managed to detect fibromyalgia in blood samples and differentiate it from other similar conditions. Kevin Hackshaw, a professor in the College of Medicine at the Ohio State University in Columbus and a rheumatologist at the university's Wexner Medical Center, led the new research.

What are the most severe symptoms of fibromyalgia?

Pain is the most obvious, and sometimes the most difficult, symptom of fibromyalgia. Other symptoms like fatigue, poor concentration, and depression or anxiety can also have a big effect on your life.

Is fibromyalgia autoimmune or neurological?

Brain imaging and studies have shown that fibromyalgia is a disorder of the central nervous system. "It's a neurological disease driven by the central nervous system," says Clauw.

Does fibromyalgia hurt all the time?

If you have fibromyalgia, one of the main symptoms is likely to be widespread pain. This may be felt throughout your body, but could be worse in particular areas, such as your back or neck. The pain is likely to be continuous, although it may be better or more severe at different times.

How do I know if I have fibromyalgia or lupus?

There are no definitive tests for either fibromyalgia or lupus, so differentiating between the two relies mostly on a thorough history of your symptoms, a physical exam, and sometimes blood tests or imaging to rule out other conditions.

What are the 7 stages of fibromyalgia?

The 7 Types of Fibromyalgia Pain

  • Hyperalgesia.
  • Widespread Muscle Pain.
  • TMJ Pain.
  • Allodynia.
  • Neuropathic Pain.
  • Headaches.
  • Abdominal and Pelvic Pain.
  • Summary.

Is fibromyalgia considered an autoimmune?

Although numerous studies have shown that fibromyalgia is not an autoimmune disease (conditions such as rheumatoid arthritis, whereby the body attacks healthy tissues), reliable research concurs that this condition does weaken your immune system by causing various abnormalities and irregularities.

Can fibromyalgia be mistaken for MS?

But despite some similarities, “for the most part, there is no mistaking symptoms of MS with fibromyalgia,” says Philip Cohen, MD, a rheumatologist, professor of medicine and professor of microbiology and immunology at the Lewis Katz School of Medicine at Temple University in Philadelphia.

What are the 8 symptoms of fibromyalgia?

8 FIBROMYALGIA SYMPTOMS YOU SHOULD KNOW

  • Pain and Tenderness. The most common and well-known symptom of fibromyalgia is the all-over aches and pains many people experience. ...
  • Fatigue. ...
  • Sleep Issues. ...
  • Mood Disorders. ...
  • Morning Stiffness. ...
  • Swelling or Tingling in Your Extremities. ...
  • Headaches. ...
  • Irritable Bowel Syndrome.

What does a fibro flare feel like?

Widespread muscle pain. Fatigue that makes completing daily activities difficult. Stiffness, especially in the morning or after a long period of inactivity. Cognitive difficulties, also known as fibro fog, including problems with memory, concentration and organization.

Can someone with fibromyalgia get the Covid vaccine?

Talk to your doctor first. Fibromyalgia treatments like antidepressants and antiseizure drugs shouldn't affect your immune system or your risk for COVID-19. It's important to keep taking your fibromyalgia medicines to avoid flares. You should consider getting vaccinated against COVID-19 when possible.

What are the 18 signs of fibromyalgia?

The 18 tender points for fibromyalgia include:

  • Lower neck in front.
  • Edge of upper breast.
  • Arm near the elbow.
  • Knee.
  • Base of the skull in the back of the head.
  • Hip bone.
  • Upper outer buttock.
  • Back of the neck.

Does fibromyalgia cause weight gain?

Numerous studies have pointed out that fibromyalgia can lead to weight gain and a sedentary lifestyle, and that extra weight can lead to more severe symptoms.

Does an MRI show fibromyalgia?

While more research is still needed, this discovery is exciting news for fibromyalgia sufferers. It means that an MRI may help both with diagnosing fibromyalgia, as well as the identification of the individual patient's unique subtype of the syndrome.

What is the root cause of fibromyalgia?

Fibromyalgia is often triggered by a stressful event, including physical stress or emotional (psychological) stress. Possible triggers for the condition include: an injury. a viral infection.

Is gabapentin used to treat fibromyalgia?

Gabapentin is an antiepileptic drug widely licensed for treatment of neuropathic pain. It is not licensed for the treatment of fibromyalgia, but is commonly used because fibromyalgia can respond to the same medicines as neuropathic pain.

What is secondary fibromyalgia?

Primary fibromyalgia is idiopathic, whereas secondary fibromyalgia occurs in association with underlying disorders such as ankylosing spondylitis, trauma, or surgery. The frequency of fibromyalgia in patients with spinal pain has not been determined.

Can you be hospitalized for fibromyalgia?

Hospitalization People with fibromyalgia are about twice as likely as others to be hospitalized for any reason, according to the Centers for Disease Control and Prevention (CDC).

What are the four stages of fibromyalgia?

Results: There were four parent stages of FM identified and labeled: 1) regional FM with classic symptoms; 2) generalized FM with increasing widespread pain and some additional symptoms; 3) FM with advanced and associated conditions, increasing widespread pain, increased sleep disturbances, and chemical sensitivity; ...

What is the new test for fibromyalgia?

There have been some promising studies on a possible diagnostic blood test for fibromyalgia. It's called an FM/a test. The test collects plasma and peripheral blood mononuclear cells (PBMC) in a small sample of your blood. It tests the concentration of cytokines within your blood sample.