What happens if C. diff goes untreated?
Emily Ross
Published Jan 08, 2026
Bacteria spilling from the colon into your abdominal cavity can lead to a life-threatening infection (peritonitis). Death. Rarely, mild to moderate C. difficile infection — but more commonly, serious infection — can quickly progress to fatal disease if not treated promptly.
Does C. diff go away on OWN?
diff go away on its own? Asymptomatic Clostridium difficile infections usually go away on their own without even being noticed. When a C. diff infection does become symptomatic, research has shown that 1 in 5 infections will resolve without medications.
Can C. diff resolve without antibiotics?
For asymptomatic carriers or patients with antibiotic-associated diarrhea, antibiotics to target C. diff aren't needed. “This will usually resolve on its own,” Dr.
Can C. diff cause long term problems?
The overall burden of C. difficile colitis is, therefore, huge. Patients with CDAD are at risk of not only treatment failure and/or early recurrence [1, 2], but, as we show here, also long-term, debilitating, recurrent disease and death.
How long before C. diff is fatal?
About 1 in 6 patients who get C. diff will get it again in the subsequent 2-8 weeks. One in 11 people over age 65 diagnosed with a healthcare-associated C. diff infection die within one month.
38 related questions foundWhen should I go to the hospital for C. diff?
It's fairly common to have diarrhea while (or after) taking an antibiotic. In most cases, C. diff is not the culprit. However, if you are experiencing significant diarrhea and other symptoms of the infection, call your healthcare provider.
What color is C. diff poop?
Greenish stools were more common among the control cases. Another study correlated nurses' response as to whether a stool was positive or not for C. difficile based on stool odor.
Can C. diff affect your brain?
Clostridium difficile, the most common cause of antibiotic-associated diarrhea, is occasionally isolated from extraintestinal sites and is usually found as part of a polymicrobial flora. We report a case of brain empyema that occurred after the recurrent intestinal carriage of a nontoxigenic strain of C. difficile.
How does C. diff cause death?
The UVA researchers found that the immune response to C. diff causes tissue damage and even death through a type of immune cell called Th17. This solves a longstanding mystery about why disease severity does not correlate with the amount of bacteria in the body but, instead, to the magnitude of the immune response.
How often is C. diff fatal?
The new study found that 1 out of every 5 patients with a healthcare-associated C. difficile infection experienced a recurrence of the infection and 1 out of every 11 patients aged 65 or older with a healthcare-associated C. difficile infection died within 30 days of diagnosis.
What's the best probiotic for C. diff?
The best studied probiotic agents in CDI are Saccharomyces boulardii, Lactobacillus GG (LGG) and other lactobacilli, and probiotic mixtures.
Is it C. diff or just diarrhea?
The diagnosis of C. difficile should be considered in patients with new and unexplained diarrhea occurring more than 3 times per day. The diagnosis is confirmed based on stool testing. There are several stool tests that can be used to diagnose C.
Can I take ibuprofen with C. diff?
Clostridium difficile infection (CDI) is a leading hospital-acquired infection and a major cause of antibiotic-associated diarrhea. Epidemiological evidence has suggested that the use of non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, naproxen and indomethacin, increases risk for CDI.
Can I pass C. diff to my family?
There is a slight chance of spreading C. difficile to a family member, especially if one is sick. Cleaning your hands well before and after contact with each other will help prevent the spread of C.
Can you have C. diff for years?
In rare cases, C. diff may not respond well to antibiotics, with infections persisting for months and even years.
How do you cure C. difficile?
diff infection can come back. Doctors sometimes recommend a treatment to help repopulate the colon with healthy bacteria. It's often done by putting another person's stool in your colon using a device called a colonoscope. The procedure is called fecal microbiota transplant (FMT).
What is the survival rate of C. diff?
Clostridium difficile infection (CDI) has emerged as a major health care–associated infection; incidence, hospitalizations, and mortality rates are increasing (1,2). Reported case-fatality rates are 6%–30% and seem to be rising (3,4).
Can you get sepsis from C. diff?
The frequent bouts of watery stool can cause dehydration, which can lead to other complications like kidney failure. And, since C. diff is an infection, it can cause sepsis. And sepsis can be fatal.
Can C. diff make you dizzy?
It can cause people to have dark yellow urine and feel thirsty, tired, dizzy, or confused. Sometimes people have C. difficile infection but don't have any symptoms. These people can still spread the infection to others.
Can C. diff cause seizures?
This can cause seizures or problems with how your heart works. Your blood pressure may drop too low and you may faint. These problems can be life-threatening. Medicine used to treat a CDI may cause vomiting, mouth irritation, or skin rashes.
Can C. diff cause fatigue?
Infection by the bacterium Clostridium difficile, or C. diff, can cause diarrhea, abdominal pain, fatigue, headache, fever, light-headedness, nausea and weight loss.
How does C. diff make you feel?
The most common signs and symptoms of mild to moderate C. difficile infection are: Watery diarrhea three or more times a day for more than one day. Mild abdominal cramping and tenderness.
What is the first line treatment for C. diff?
For an initial episode of nonsevere C. difficile infection, oral vancomycin or oral fidaxomicin is recommended.
Does C. diff have a smell?
difficile associated disease? Frequent, foul smelling, watery stools characterize mild cases of C. difficile disease. More severe symptoms, indicative of pseudomembranous colitis, include diarrhea that contains blood and mucous and abdominal cramps.
Does your stomach swell with C. diff?
difficile bacteria produces toxins as it grows. These toxins irritate the intestinal lining, leading to swelling, pain, and diarrhea.