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What happens if you take naproxen and ibuprofen together?

Author

Emma Payne

Published Jan 09, 2026

ibuprofen naproxen

Using ibuprofen together with naproxen is generally not recommended. Combining these medications may increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.

Is it OK to take ibuprofen and naproxen together?

The bottom line for weekend warriors is that you cannot combine ibuprofen and naproxen unless it is time for another dose of either medication. If you need additional pain relief, you can combine aspirin, naproxen, or ibuprofen with acetaminophen.

How far apart can you take naproxen and ibuprofen?

Most adults can take up to 1,200 mg of ibuprofen every 24 hours. People can take up to 600 mg of Aleve every 24 hours. However, a person should never combine these drugs.

What happens if you take 2 naproxen 500mg?

As a side note, do not take more than two 500 mg tablets in 24 hours without talking to your doctor. Taking a third tablet will result in an increased risk side effects including a potential decrease in kidney function.

Is naproxen stronger than ibuprofen?

Both drugs were well-tolerated. Another small study comparing naproxen to ibuprofen found both drugs to be helpful in reducing stiffness, resting pain, movement pain, night pain, interference of the disease with daily activities, and overall disease severity. Naproxen was found to be more effective in this study.

38 related questions found

Is naproxen a strong painkiller?

Naproxen is a powerful anti-inflammatory painkiller which is used to relieve pain and inflammation associated with a range of different health conditions (such as arthritis, gout or menstrual pain).

What drugs should not be taken with naproxen?

Some products that may interact with this drug are: aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as losartan, valsartan), cidofovir, corticosteroids (such as prednisone), lithium, "water pills" (diuretics such as furosemide).

How fast does naproxen work?

This medicine usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of this medicine. Check with your doctor first before changing dosage forms (eg, tablets, suspension).

What is the strongest anti-inflammatory?

“We provide sound evidence that diclofenac 150 mg/day is the most effective NSAID available at present, in terms of improving both pain and function,” writes Dr da Costa.

Can naproxen make you pass out?

This medicine may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Even if taken at bedtime, it may cause some people to feel drowsy or less alert on arising.

What drugs should not be taken with ibuprofen?

Drugs that may interact with ibuprofen include :

  • lithium.
  • warfarin.
  • oral hypoglycemics.
  • high dose methotrexate.
  • medication for lowering blood pressure.
  • angiotensin-converting enzyme inhibitors.
  • beta-blockers.
  • diuretics.

Can I take 2 naproxen 220 mg?

take 1 tablet every 8 to 12 hours while symptoms last. for the first dose you may take 2 tablets within the first hour. do not exceed 2 tablets in any 8- to 12-hour period. do not exceed 3 tablets in a 24-hour period.

How much stronger is naproxen than ibuprofen?

Effectiveness of Naproxen and Ibuprofen

As far as effectiveness goes, a dose of 440mg naproxen is approximately equivalent to a dose of 400mg ibuprofen.

What is better to reduce swelling ibuprofen or naproxen?

Ibuprofen and naproxen are so similar that overall, there's not one that is better than the other for adults. Adults and adolescents ages 12 and older might consider ibuprofen or naproxen for different types of pain and inflammation, including: Fever. Muscle or joint pain.

How long does it take for naproxen to work on inflammation?

This medicine usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of this medicine. Check with your doctor first before changing dosage forms (eg, tablets, suspension).

Should I take naproxen in the morning or at night?

According to a new study, published in the journal Scientific Reports, using NSAIDs during the daytime might be preferable to taking them at night (such as before bed).

What happens if I take naproxen too close together?

Combining naproxen with other NSAIDs increases your risk of stomach and intestinal bleeding.

How long does naproxen last for pain?

Naproxen (Aleve) and ibuprofen both belong to a class of medications called non-steroidal anti-inflammatory drugs (NSAIDs). They are similar and usually used for mild to moderate pain. However, naproxen (Aleve) lasts for 8 to 12 hours, while ibuprofen only lasts for 4 to 6 hours.

What should you not take with spironolactone?

Avoid taking salt substitutes that contain potassium or potassium supplements while taking spironolactone. Try to avoid foods high in potassium (such as avocados, bananas, coconut water, spinach, and sweet potato) because eating these foods may lead to potentially fatal hyperkalemia (high blood potassium levels).

Does ibuprofen make you sleepy?

Can ibuprofen (Advil) make you sleepy? No. Drowsiness is not a known side effect of ibuprofen (Advil).

Why can't you lay down after taking naproxen?

Do not lie down for at least 10 minutes after taking this drug. The dosage is based on your medical condition and response to treatment. To reduce your risk of stomach bleeding and other side effects, take this medication at the lowest effective dose for the shortest possible time.

Does naproxen affect sleep?

In addition to inhibiting prostaglandin synthesis, NSAIDs also suppress the nocturnal surge in melatonin and attenuate the nocturnal decrease in body temperature. Any one or a combination of these effects could result in alteration of sleep patterns after NSAID ingestion.

Is it OK to take 4 naproxen?

People can try taking 550 mg of naproxen sodium every 12 hours and may increase it to 825 mg if needed. The daily dose should not exceed 1,375 mg.

Is naproxen good for toothache?

“Anti-inflammatory drugs such as ibuprofen, Advil, Motrin or naproxen work well with dental pain because they reduce inflammation,” says Huang. Recent data has shown the combination of Advil (ibuprofen) and Tylenol (acetaminophen) is as effective as prescription opioids for tooth pain.

Can you drink coffee while taking naproxen?

Advil and naproxen (and other drugs), such as ibuprofen, ketoprofen, or naproxen, may be contained within them. If you take this medication, you should avoid coffee, tea, cola, energy drinks and other sources of caffeine.