What is the TikTok Benadryl challenge?
William Rodriguez
Published Jan 09, 2026
Physicians should be aware of the TikTok Benadryl challenge, a social media trend in which teens are encouraged to ingest higher than recommended doses of the over-the-counter allergy medicine diphenhydramine (Benadryl) in order to achieve a “high.” Teens may perceive the over-the-counter drug to be relatively safe, ...
How much Benadryl do you take for a challenge?
The challenge encourages users to take upwards of 12 tablets at a time, while the directions say children age 6 to 12 should take one tablet every 4 to 6 hours, and adults should take no more than 2 tablets every 4 to 6 hours.
When should I take Benadryl TikTok?
A challenge posted on TikTok known as the “Benadryl challenge” encourages viewers to take large doses of the antihistamine to induce hallucinations. Experts say excessive doses of Benadryl can cause serious health issues, even causing death in some situations.
What is Benadryl do?
Diphenhydramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, itching, watery eyes, itchy eyes/nose/throat, cough, runny nose, and sneezing. It is also used to prevent and treat nausea, vomiting and dizziness caused by motion sickness.
How long does it take for Benadryl to kick in?
How long does it take diphenhydramine (Benadryl) to start working? Diphenhydramine (Benadryl) starts to work pretty quickly. You can expect to it to kick in within about 15 to 30 minutes. Its full effects can be felt around 2 hours after your dose.
28 related questions foundWhat do teens use Benadryl for?
Benadryl, or diphenhydramine, is a common over-the-counter allergy medicine. It treats symptoms like rash, itching, watery eyes, cough, runny nose and sneezing. The Benadryl challenge, which started trending on TikTok in 2020, encourages teens to take an excessive amount as a deliriant.
What happens if you take too much Benadryl?
Too much Benadryl can cause a wide variety of side effects, ranging from sleepiness and dry mouth to coma and possibly death. If you suspect someone has taken too much Benadryl and they collapse, have a seizure, or have trouble breathing, call 911 immediately.
Is Benadryl unsafe?
“Taking higher than recommended doses of the common over-the-counter (OTC) allergy medicine diphenhydramine (Benadryl) can lead to serious heart problems, seizures, coma or even death,” said the FDA in the warning.
Why was Benadryl taken off the market?
09-24-2020 FDA Drug Safety Communication
The U.S. Food and Drug Administration (FDA) is warning that taking higher than recommended doses of the common over-the-counter (OTC) allergy medicine diphenhydramine (Benadryl) can lead to serious heart problems, seizures, coma, or even death.
Is Benadryl good for anxiety?
Advantages. One of the biggest advantages of using an OTC medication such as Benadryl to treat anxiety is that it is fast-acting and convenient. These qualities can be helpful if you need to reduce symptoms of mild anxiety quickly. Because Benadryl causes many people to feel drowsy, it can also help with sleep.
Is it OK to take Benadryl every night?
Is it safe to take diphenhydramine every night? You should not take diphenhydramine every night. While it may be helpful during limited periods of insomnia, your body will build up a tolerance for the medication over time, and it will no longer have the desired effect.
Can I take 3 Benadryl?
Oral Benadryl products shouldn't be taken more than 6 times each day. For adults and children over 12 years of age, the maximum is 300 mg each day.
Can I take 100mg of Benadryl to sleep?
What is the maximum dose of diphenhydramine for sleep? When used as a sleep aid the maximum recommended dosage is 76mg for diphenhydramine citrate or 50mg for diphenhydramine hydrochloride.
Who should not take Benadryl?
Who should not take BENADRYL?
- overactive thyroid gland.
- increased pressure in the eye.
- closed angle glaucoma.
- high blood pressure.
- stenosing peptic ulcer.
- blockage of the urinary bladder.
- enlarged prostate.
- an inability to completely empty the bladder.
Can a 10 year old take 25 mg of Benadryl?
Standard Benadryl dosage for children ages 6 to 11: One tablet/capsule (25 mg) every four to six hours. Maximum Benadryl dosage for children ages 6 to 11: One tablet/capsule (25 mg) every four hours to a maximum of six tablets (150 mg) in 24 hours.
Is it OK to take Benadryl every day?
Benadryl is recommended only as a short-term treatment for people with symptoms of allergies or other conditions that the drug treats. If you take Benadryl long term, you may develop long-term side effects of the medication.
Is ZzzQuil just Benadryl?
The majority of them — ZzzQuil, TylenolPM and Unisom SleepGels — contain diphenhydramine as the active ingredient, the same compound in Benadryl. (Unisom SleepTabs use doxylamine, another antihistamine.)
Is 75 mg of Benadryl too much?
A: Diphenhydramine HCl comes in 25 mg and 50 mg strengths (Benadryl is a common brand). For adults and teens, the diphenhydramine dosage is 25 to 50 mg every 4 to 6 hours. The maximum amount you should take in one day is 300 mg.
How much Benadryl is fatal for adults?
Death may occur within 2 hours of overdose, with a fatal dose for children estimated to be 500 mg and for adults 20 to 40 mg/kg.
Is Benadryl habit forming?
Diphenhydramine, a major ingredient used to make Benadryl, is highly addictive. Although the drug is used to treat conditions like insomnia, nausea, the common cold, and tremors for Parkinson's patients, if regularly ingested in liquid, tablet, or capsule form, it can become addictive.
Can Benadryl make you gain weight?
Histamine also acts as a neurotransmitter in our brains playing a key role in wakefulness and preventing sleep, which is why Benadryl (an anti-histamine) makes you sleepy. This effect may actually one of the reasons why anti-histamines can result in weight gain.
Can Benadryl make you have weird dreams?
Drug-induced nightmares and vivid dreams are most commonly reported with first-generation antihistamines such as diphenhydramine (Benadryl) (which are often found in over-the-counter sleep and allergy medications).
Does Benadryl cause Alzheimer's?
Researchers have discovered a significant link between high use of anticholinergic drugs – including popular non-prescription sleep aids and the antihistamine Benadryl (diphenhydramine) – and increased risk of developing dementia and Alzheimer's disease in older people.
Does Benadryl work like Xanax?
However, OTC antihistamines (i.e., Benadryl/diphenhydramine) have been recommended as a short-term solution for anxiety symptoms. While there is likely not any harm in taking an occasional OTC antihistamine as an over-the-counter Xanax alternative, the sedating side effects are not ideal for regular use.
What is the 3 3 3 rule for anxiety?
Follow the 3-3-3 rule.
Look around you and name three things you see. Then, name three sounds you hear. Finally, move three parts of your body — your ankle, fingers, or arm.