Why was Prozac taken off the market?
Noah Mitchell
Published Jan 07, 2026
In 2018, the manufacturer Teva Pharmaceuticals issued a voluntary nationwide recall of fluoxetine (Prozac), because of irregular testing results. Fluoxetine is an antidepressant medication used to treat conditions like depression, obsessive-compulsive disorder, and panic attacks.
Why you should not take Prozac?
Warnings. The use of Prozac can carry risks, including the potential for clinical worsening and in rare cases, increased thoughts of suicide. 6 Serotonin syndrome can also occur, particularly if used in conjunction with certain other medications. Close monitoring by your psychiatrist or doctor is important.
What are the long term effects of Prozac?
The chronic use of antidepressants like Prozac could lead to a blunted emotional response, changes in mood, and increased experience of agitation, anxiety, insomnia, restlessness, and nervousness, with the highest rates among people taking the highest doses [5].
Is Prozac harmful to the brain?
No one really understands how normal functioning of the brain may be impaired by Prozac-type antidepressants in the long run. Indeed, one worrisome study, published in the March 2000 issue of Brain Research, indicates that Prozac and Zoloft may be toxic to the very cells they target in the brain.
Is Prozac still prescribed?
Prozac is a commonly prescribed antidepressant. Along with its generic version, fluoxetine, Prozac was prescribed more than 27 million times in the United States in 2019. Even though it is common, Prozac is still a medication that can have serious side effects, including overdose.
31 related questions foundWhat is the #1 antidepressant?
Zoloft is the most commonly prescribed antidepressant; nearly 17% of those surveyed in the 2017 antidepressant use study reported that they had taken this medication.
Is Prozac stronger than Zoloft?
Which is More Effective? Both Prozac and Zoloft are considered powerful mental health medications, comparably effective at treating depression and reducing anxiety for the patients who take them. A few clinical trials suggest that Zoloft may have less serious side effects than Prozac.
Does Prozac cause dementia?
According to the study, popular Prozac-like pills known as SSRIs — selective serotonin reuptake inhibitors — and other antidepressants are associated with a twofold increase in the odds of developing some form of dementia, including Alzheimer's.
Does your brain go back to normal after antidepressants?
"The fact that antidepressant withdrawal can be so prolonged suggests that the drug has changed the brain and that those changes are taking a very long time to return to normal and it may be the case that sometimes they don't go back to normal."
Does Prozac cause brain fog?
Serious side effects are rare (less than 1 in 100 people). Tell your straight away GP if any of these side effects occur: Brain fog (trouble focusing, memory problems, not thinking clearly and losing your balance can all be signs of low sodium levels)
How long can you stay on Prozac?
How long will I need to take fluoxetine for? Most people take fluoxetine for at least six to 12 months after they start to feel better. If you have suffered from depression in the past, you should keep taking this medication for at least two years after you start to feel better.
Can you take Prozac for years?
Sharing the Research: When patients ask about the long-term use of antidepressant medication, the truth is there really isn't any. Prozac has been around since the 1980s but published long-term studies of antidepressant medications range from 3 to 15 years.
Does long term use of Prozac cause memory loss?
Finding of the study supports the concept that long-term use of fluoxetine does not impair memory and psychomotor function but improves it significantly. It may be preferred in patients who operate machinery, drive vehicle, or require alertness for the work.
Does Prozac make you lazy?
Serotonin reuptake inhibitors (SSRIs) like escitalopram (Lexapro), citalopram (Celexa), paroxetine (Paxil), and fluoxetine (Prozac), taken for depression or anxiety, can make you feel sleepy.
Does Prozac change your personality?
People taking Prozac or other anti-depressants may experience personality changes for a range of reasons: The stress of waiting for improvement may worsen their mental state or the anti-depressant may produce symptoms of a different, undiagnosed mental illness.
What can you take instead of Prozac?
Selective serotonin reuptake inhibitors (SSRIs).
SSRIs include fluoxetine (Prozac), paroxetine (Paxil, Pexeva), sertraline (Zoloft), citalopram (Celexa) and escitalopram (Lexapro).
Do antidepressants shorten your life?
The analysis found that in the general population, those taking antidepressants had a 33 percent higher risk of dying prematurely than people who were not taking the drugs. Additionally, antidepressant users were 14 percent more likely to have an adverse cardiovascular event, such as a stroke or a heart attack.
Do antidepressants destroy your brain?
We know that antipsychotics shrink the brain in a dose-dependent manner (4) and benzodiazepines, antidepressants and ADHD drugs also seem to cause permanent brain damage (5).
What is fuzzy brain?
What is brain fog? While it's not a medical term, brain fog describes a feeling that you don't have full mental clarity—maybe you're having trouble remembering something or difficulty focusing on a thought or idea.
What are the safest antidepressants to take?
Among the newer antidepressants, bupropion and venlafaxine were associated with the highest case fatality rates. In addition, among SSRIs, citalopram and fluvoxamine appeared to be related to higher mortality rates in overdose, whereas fluoxetine and sertraline were the safest [188].
Can antidepressants cause ALS?
In these analyses, antidepressant use was still associated with a higher subsequent risk of ALS (OR 2.0, 95% CI 1.8–2.3) and patients with ALS still had a higher risk of antidepressant use (OR 13.7, 95% CI 10.8–17.4) after the index date compared to controls.
What is Sundowning behavior?
They may experience sundowning—restlessness, agitation, irritability, or confusion that can begin or worsen as daylight begins to fade—often just when tired caregivers need a break. Sundowning can continue into the night, making it hard for people with Alzheimer's to fall asleep and stay in bed.
What is the strongest antidepressant?
The most effective antidepressant compared to placebo was the tricyclic antidepressant amitriptyline, which increased the chances of treatment response more than two-fold (odds ratio [OR] 2.13, 95% credible interval [CrI] 1.89 to 2.41).
What are the top 5 antidepressants?
Top 5 antidepressants to treat depression
- Citalopram.
- Escitalopram.
- Fluoxetine.
- Fluvoxamine.
- Paroxetine.
- Sertraline.
Is Prozac a happy pill?
The original “happy pill” was fluoxetine, more commonly known as Prozac. This medication, approved for use in 1987, was the first drug of its kind to be prescribed and marketed on a large scale. The use of this medication is very common, especially for the treatment of depression, but it is not without its risks.